Return on Health is a podcast about longevity, prevention and the future of health — built on one rule: listen to every side, pressure-test every claim, and keep science and common sense at the center.
Biogerontologist Dr. Matt Kaeberlein on what rapamycin has really shown, how thin the human evidence still is, why NAD supplements do not hold up, and which biological age tests are worth anything.
Why Kaeberlein questions whether the Hallmarks of Aging are causes or consequences. What rapamycin has shown across animal models, what transplant medicine tells us about safety at very different doses, and why he takes it himself while calling the human evidence unfinished. Plus NAD, supplement stacking and biological age clocks.
Every episode pressure-tests one question. Researchers, founders, clinicians, skeptics — then the data. Filter by topic, or start from the top.
















Health content optimizes for clicks. We optimize for decisions you can actually make. Fewer claims, more context, honest uncertainty.
Researchers, founders, clinicians, skeptics, innovators — and we pressure-test their ideas. Some viewpoints align, some clash. That is the point.
Most systems wait until something breaks. Longevity, performance and prevention start decades earlier. We make that case, episode by episode.
When evidence is thin, we say so. When something works, we say so. Trends die fast; fundamentals compound. We stay with the fundamentals.
Niko and Miguel met during their Master's at NOVA SBE. Late-night debates about health, medicine and broken incentives turned into a shared frustration with the system. And, eventually, this podcast.
● Host 01